姓名：夏成才
职称：教授（四级岗），硕士生导师
联系邮箱：xiachc@163.com, ccxia@sdfmu.edu.cn
联系电话：13854841902
学习经历：
1996.09—2000.07 青岛化工学院，化学工程，学士
2003.09—2006.06 浙江工业大学，生物化工，硕士
2012.09—2016.01 浙江工业大学，药物化学，博士
工作经历：
2006.07—2008.11 泰山医学院药学院，助教
2008.12—2014.11 泰山医学院药学院，讲师
2014.12—2021.07 山东第一医科大学药学院，副教授
2021.08—至今 山东第一医科大学药学院，教授
研究方向：
1. 有机合成方法学及药物合成新工艺研究；
2. 合理药物设计、合成与生物活性研究；
主要学术任职：
1. 中国医药教育协会临床用药评价委员会，委员；
2. 山东生物医学工程学会医美药分子工程专业委员会，委员；
3. Org. Lett., Org. Chem. Front., Adv. Synth. Catal., Org. Biomol. Chem.等期刊审稿人
主要获奖情况：
1. 泰安市第十四批拔尖人才，泰安市，2019；
2. 山东省高等学校科学技术奖，定位基团导向C-X键构建及在有机合成中的应用研究。
第1完成人，2019；
3. 山东省研究生优秀科研成果奖二等奖2项，三等奖2项；
4. 山东省优秀硕士论文指导老师，4篇；
主持科研课题：
1. 山东第一医科大学学术提升计划，2019LJ003，创新药物早期成药性及临床前研究，2019-2024，5000万，参与。
2. 山东省医药卫生科技发展计划项目，5-取代-1,3-二芳基-1,2,4-三氮唑类化合物设计、合成及活性研究，2021.01-2022.12，2万元，主持。
3. 山东省自然基金面上项目（联合专项），ZR2017LB006，苯并[e]吡咯[1,2-a]氮杂卓衍生物的合成及生物活性研究, 2017.08-2019.12，6万元，主持。
4. 山东省高等学校科技计划项目，J17KA248，磺酰胺席夫碱导向的C-H活化反应C-S键形成研究，2017.08-2018.12，3.5万元，主持。
5. 山东省医药卫生科技发展计划，2015WSB31006，3-烷基取代喹诺酮衍生物的设计、合成及抑菌活性研究，2015/12-2018/12，2万元，主持。
6. 泰安市科技发展计划，201440774-02，对氯苯基硼酸酯及其系列产品清洁化生产工艺研究，2014/01-2016/12，3万元，主持。
近五年代表性论文（限第一作者和通讯作者）：
1. Xiao Yu, Shengjie Song, Zenghui Zhang, Yi Liu, Mei Zhang, Wenjing Zhu, Guiyun Duan, Pengfei Zhang, Yafei Ji, and Chengcai Xia*. Electrochemical Oxidative Carbon-atom Multi-functionalization and N-cyanation of Imine: Synthesis of (Z)-N'-cyano-N-carbamimidothioate. Adv. Synth. Catal., 2023, doi.org/10.1002/adsc.202300224
2. Mei Zhang, Xiao Yu, Wenjing Zhu, Yi Liu, Zenghui Zhang, Jinbo Zhao, Chengcai Xia,* and Ke Li*. Iron-Catalyzed Synthesis of Benzosultams from N‑Phenyl‑N‑(prop-2-yn-1-yl)benzenesulfonamide and Benzenesulfonyl Hydrazine. Org. Lett., 2023, 25, 603−607.
3. Yi Liu, Wenjing Zhu, Xiao Yu, Hongyan Liu, Zenghui Zhang, Mei Zhang, Jinbo Zhao, Yacong Wang,* and Chengcai Xia,*. Synthesis of Ethyl 3-(1-Acetyl-3-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-2,2-difluoropropanoate from N-Allyl-N’-benzylideneacetohydrazide and Ethyl 2-Bromo-2,2-difluoroacetate. Adv. Synth. Catal., 2022, 364, 4300– 4304.
4. Xiao Yu, Zhihong Ma,* Wenjing Zhu, Hongyan Liu, Zenghui Zhang, Yi Liu, Mei Zhang, Jinbo Zhao, Pengfei Zhang, and Chengcai Xia*.Tandem Reduction, Ammonolysis, Condensation, and Deamination Reaction for Synthesis of Benzothiadiazines and 1‑(Phenylsulfonyl)‑1H‑benzimidazoles. J. Org. Chem. 2022, 87, 14738−14752.
5. Xiao Yu, Wenjing Zhu, Hongyan Liu, Yi Liu, Hongshuang Li, Junfen Han,* Guiyun Duan, Zhushuang Bai, Pengfei Zhang and Chengcai Xia* Practical chemoselective aromatic substitution: the synthesis of N-(4-halo-2-nitrophenyl) benzenesulfonamide through the efficient nitration and halogenation of N-phenylbenzenesulfonamide. Org. Biomol. Chem., 2022, 20, 5444–5451.
6. Zenjing Zhu, Yu Chen, Xiao Yu, Hongyan Liu, Zheng Zhang, Fuqiang Wen, Yi Liu, Pengfei Zhang, Chengcai Xia,* and Furong Li*. Synthesis of (E)-1-(phenyldiazenyl)cyclohexyl Benzoate from N-(cyclohexylideneamino)aniline and Benzoyl Peroxide. ChemistrySelect, 2022, 7, e202104597.
7. Hongyan Liu, Zengfen Pang*, Liqiang Hao, Jian Sun, Zheng Zhang, Fuqiang Wen, and Chengcai Xia*. Sulfonylimination of Proline with Sulfonylazides Involving Aldehyde-Induced Decarboxylation Coupling. Org. Lett., 2021, 23, 4, 1234–1238.
8. Jian Sun, Haoyi Sun, Liqiang Hao, Hongyan Liu, Zheng Zhang, Fuqiang Wen, Hongshuang Li, Guiyun Duan, Guirong You, Chengcai Xia*. Metal-Free Synthesis of Pyrrole-imidazole Alkaloids via a Tandem C−N, C−C coupling Protocol. Adv. Synth. Catal., 2021, 363, 7, 1882–1886.
9. Hongyan Liu, Bin Zhang, Wei Zhao, Xiao Yu, Wenjing Zhu, Chengcai Xia,* and Yanmeng Zhou*.Base-Mediated Coupling Reactions of Benzenesulfonyl Azides with Proline: Synthesis of Proline-Derived Benzenesulfonamides. ACS Omega 2021, 6, 34796−34804.
10. Liqiang Hao, Hongyan Liu, Zheng Zhang, Fuqiang Wen, Chengcai Xia,* Zengfen Pang*. Cascade reaction to 1H-pyrazoles from hydrazonesvia sodium nitritepromoted dual C–C/C–N formation, annulation and aromatization with 1,2-dichloroethane. Chinese Chemical Letters, 2021 (32) 2309–2312.
11. Xiaojun Li, Shangtie Liao, Yu Chen, Chengcai Xia,* and Guodong Wang. Cobalt(II) nitrate promoted cyclization of benzoyl hydrazone for the synthesis of 2,5-diphenyl-1,3,4-oxadiazole derivatives. Journal of Chemical Research, 2021, 1038-1041.
12. Xiaopan Fu, Yangyang Wang, Jinyue Yang, Gaorong Wu, Chengcai Xia*, Ji, Yafei. Fully Substituted Pyrazoles Assis ted Palladium-Catalyzed Late-Stage Arylation of C(sp(2))-H Bond. Chin. J. Org. Chem., 2020, 40, 4305–4314.
13. Lili Zhang, Kezuan Deng, Gaorong Wu, Jinyue Yang, Shibiao Tang, Xiaopan Fu,*, Chengcai Xia*, and Yafei Ji*. Ruthenium(II)-Catalyzed α-Fluoroalkenylation of Oxime Ethers with gem-Difluorostyrenes via C–H Activation and C–F Cleavage. J. Org. Chem., 2020, 85, 19, 12670–12681.
14. Liqiang Hao, Guodong Wang, Jian Sun, Jun Xu, Hongshuang Li, Guiyun Duan, Chengcai Xia*, and Pengfei Zhang. From Phenylhydrazone to 1H-1,2,4-Triazoles via Nitrification, Reduction and Cyclization. Adv. Synth. Catal., 2020, 362, 8, 1657-1662.
15. Xiaobo Xu, Chengcai Xia*, Xiaojun Li, Jian Sun and Liqiang Hao. Visible-light-induced aerobic C3-H fluoroalkoxylation of quinoxalin-2(1H)-ones with fluoroalkyl alcohols. RSC Adv., 2020, 10, 2016–2026.
16. Guodong Wang, Jian Sun, Kai Wang, Junfen Han, Hongshuang Li, Guiyun Duan, Guirong You, Furong Li and Chengcai Xia*. Palladium-catalyzed direct C-H nitration and intramolecular C-H functionalization for the synthesis of 3-nitro-1-(phenylsulfonyl)-1H-indazole derivatives. Org. Chem. Front., 2019, 6, 1608–1612.
17. Xiaopan Fu, Jinyue Yang, Kezuan Deng, Lingyan Shao, Chengcai Xia* and Yafei Ji*. Tandem C−C/C−N Formation via Palladium-Catalyzed C−H Activation/Styrenation and Sequential Annulation of O‑Methylketoxime with Styrenes. Org. Lett. 2019, 21, 3505−3509.
18. Zhenjiang Wei, Sijia Qi, Yanhao Xu, Hao Liu, Junzhen Wu, Hongshuang Li, Chengcai Xia,* and Guiyun Duana*. Visible Light-Induced Photocatalytic C& H Perfluoroalkylation of Quinoxalinones under Aerobic Oxidation Condition. Adv. Synth. Catal. 2019, 361, 5490– 5498.
19. Jian Sun, Guodong Wang, Liqiang Hao, Junfen Han, Hongshuang Li, Guiyun Duan, Guirong You, Furong Li, and Chengcai Xia*. Copper-Catalyzed Tandem C- H/N-H Activation, Cyclization [4+2] and Dehydration of Arylamides with Formamide: Synthesis of 4(3H)-Quinazolinones Derivatives. ChemCatChem 2019, 11, 2799–2802.
20. Guirong You, Dan Xi, Jian Sun, Liqiang Hao and Chengcai Xia*. Transition-metal- and oxidant-free three-component reaction of quinoline N-oxides, sodium metabisulfite and aryldiazonium tetrafluoroborates via a dual radical coupling process. Org. Biomol. Chem., 2019, 17, 9479–9488.
21. Xiaobo Xu, Zhengzhou Chu and Chengcai Xia *. Transition-metal free oxidative C–H etherification of acylanilines with alcohols through a radical pathway. Org. Biomol. Chem., 2019, 17, 6346–6350.
22. Ke-Zuan Deng, Li-Li Zhang, Ye-Feng Chen, He-Xin Xie, Xiao-Bo Xu, Cheng-Cai Xia * and Ya-Fei Ji*. Copper-mediated direct thiolation of aryl C–H bonds with disulfides. Org. Biomol. Chem., 2019, 17, 7055–7065.
23. Junfen Han, Guodong Wang, Jian Sun, Hongshuang Li, Guiyun Duan, Furong Li, Chengcai Xia*. Photoredox-catalyzed perfluoroalkylation of aminoquinolines with hypervalent iodine(III) reagents that contain perfluoroalkanoate. Catalysis Communications, 2019, 118, 81–85.
24. Junfen Han, Kai Wang, Guirong You, Guodong Wang, Jian Sun, Guiyun Duan, Chengcai Xia*. Heterogeneous copper-catalyzed CeS coupling via insertion of sulfur dioxide: A novel and regioselective approach for the synthesis of sulfurcontaining compounds. Catalysis Communications. 2019, 128: 105708.
25. Junfen Han, Guodong Wang, Jian Sun, Hongshuang Li, Guiyun Duan, Furong Li, Chengcai Xia*. Solid-supported Pt-catalyzed remote C-H etherification of arylamines: A simple and practical approach for the synthesis of aromatic ethers. Catalysis Communications. 2019,129: 105722.
26. Qingqing Liu, Xinxin Luo, Shujie Wei, Youzhao Wang, Jiaxin Zhu, Yi Liu, Fenglei Quan, Meng Zhang, Chengcai Xia*. Palladium-catalyzed direct ortho CAX bond construction via C-H activation of azobenzenes: Synthesis of (E)-1,2-b(2,6-dibromo(chloro)-phenyl)diazene. Tetrahedron Letters 2019, 60, 1715–1719.
27. Xiao-Pan Fu, Shi-Biao Tang, Jin-Yue Yang, Li-Li Zhang, Cheng-Cai Xia,* and Ya-Fei Ji*. Cascade Reaction for the Synthesis of Carbolines from O-Methyl-ketoximes and Styrenes via Palladium-Catalyzed C–H Activation and Sequential Annulation. Eur. J. Org. Chem. 2019, 5974–5977.
28. Ruize Zhang, Guodong Wang, Hongshuang Li, Guiyun Duan*, Kai Wang and Chengcai Xia*. Strong-acid Cation Exchange Resin Catalyzed Synthesis of Bis(indolyl)methanes in Water. Chinese Journal of Organic Chemistry，2019，39(5): 1429–1435.
29. Guirong You, Kai Wang, Xiaodan Wang, Guodong Wang, Jian Sun, Guiyun Duan, and Chengcai Xia*. Visible-Light-Mediated Nickel(II)-Catalyzed C–N Cross-Coupling in Water: Green and Regioselective Access for the Synthesis of Pyrazole-Containing Compounds. Org. Lett.,2018, 20, 4005-4009.
30. Shaofan Wang, Qipeng Zhao, Guodong Wang, Kai Wang, and Chengcai Xia*. Palladium-catalyzed Direct O-Nitrification of Azobenzenes with Co(NO3)2•6H2O via C-H Activation. Chin. J. Org. Chem. 2018, 38, 1849-1854.
31. Guodong Wang, Junfen Han, Kai Wang, Hongshaung Li, Guiyun Duan, Chengcai Xia*, Furong Li. Methoxylation on the C5 and C6 positions of quinolines with methanol. Catalysis Communications, 2018, 114, 37-41.
